منابع مشابه
Large granular lymphocytosis after transplantation
Post-transplant lymphoproliferative disorders (PTLD) represent a heterogeneous group of diseases that occur following transplantation. Large granular lymphocytic (LGL) lymphocytosis is one type of PTLD, ranging from reactive polyclonal self-limited expansion to oligo/monoclonal lymphocytosis or even to overt leukaemia. LGL lymphocytosis in transplant recipients may present as a relatively indol...
متن کاملLymphocytosis: T-cell large granular lymphocyte leukemia.
A 50-year-old female with low-grade chronic anemia and no other medical problems was evaluated when her hemoglobin fell to 8.2 g/dL. She had no adenopathy or hepatosplenomegaly. Her white cell count was 7.7 109/L with a lymphocyte count of 6.2 109/L, platelets 498 109/L, and reticulocyte count that was normal. Serum electrophoresis and rheumatoid factor were negative and ANA was weakly positive...
متن کاملLarge granular lymphocytosis associated with rheumatoid arthritis.
A 74 year old woman with rheumatoid arthritis, hepatosplenomegaly, neutropenia, and peripheral blood lymphocytosis is described. The lymphocytes had a large granular morphology and expressed a CD3+ CD8+ Leu7+ surface antigen phenotype. They did not have natural killer cell function. Southern analysis of the lymphocyte DNA using two restriction enzymes showed a rearranged pattern for the T cell ...
متن کاملLarge granular lymphocytosis with severe neutropenia following ipilimumab therapy for metastatic melanoma
To the editor Cytotoxic T-lymphocyte antigen-4 (CTLA-4), a molecule present on activated T cells, is a homologue of CD28 that inhibits B7 co-stimulatory molecules expressed on mature antigen presenting cells. Ipilimumab is a fully humanized monoclonal antibody against CTLA-4 [1]. Ipilimumab is FDA approved in the United States for treatment of unresectable or metastatic melanoma [1,2]. We repor...
متن کاملA morphologic and immunologic study of the large granular lymphocyte in neutropenia with T lymphocytosis.
We report four patients with expansion of a unique population of lymphocytes that is consistently associated with neutropenia. Two patients also had rheumatoid arthritis and autoantibodies. The lymphocytes contained many cytoplasmic azurophilic granules, which possessed strong acid phosphatase activity. Multiple cytoplasmic parallel tubular arrays were observed ultrastructurally. These granular...
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ژورنال
عنوان ژورنال: The American Journal of Pathology
سال: 2003
ISSN: 0002-9440
DOI: 10.1016/s0002-9440(10)63703-0